SYNTHESIS OF N-ALKYL AMINO LACTAM DERIVATIVES

Phi Thi Dao

Abstract


Bengamides are sponge-derived natural products of mixed biosynthesis (polyketides and
amino acids), the first two members, isolated from Jaspidae sponges in coral surrounding Fiji
islands, were reported in 1986. The main structural variation is located on the 3-
aminocaprolactam moiety, and displays a wide range of biological activities, including
antitumor, antibiotic, and anthelmintic properties. These interesting biological activities have
made bengamides popular targets for synthesis and biological studies. There have been some
reports on diverse modifications of the caprolactame unit, and indication that N-substitution on
caprolactam greatly influences the antitumor activity. In this paper, we reported the method for
synthesis of 6 amino lactams containing an additional N-alkyl group (4a-4c) and (8a-8c) for
further synthesis of new bengamide analogues. Their structures were established by MS and
NMR spectroscopies.


Keywords


bengamides, amino-lactams, cytotoxic activity.

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DOI: https://doi.org/10.15625/2525-2518/54/2C/11849 Display counter: Abstract : 82 views. PDF : 71 views.

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Published by Vietnam Academy of Science and Technology