SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A

Le Duc Anh

Abstract


Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 were
prepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylation
reactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,
LU, RD and Fl. The result showed that both compounds exhibited no activity against the tested
cell lines.


Keywords


murrayafoline A, N-alkylation, cytotoxicity, sesquiterpene, conjugate.

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DOI: https://doi.org/10.15625/2525-2518/54/2C/11880 Display counter: Abstract : 163 views. PDF : 118 views.

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Published by Vietnam Academy of Science and Technology