pH/TEMPERATURE SENSITIVE PENTABLOCK BASED ON D,L-SERINE

Dai Phu Huynh

Abstract


For recent decades, researchers have been increasing their attention to pH/temperature-sensitive polymers as drug/protein delivery systems. In this research, we aim to synthesize a new pH/temperature sensitive pentablock based on D,L-Serine. Amino groups of D,L-Serine were modified with benzenesulfonyl chloride in order to create sulfonamide groups as desired pH-sensitive groups. Pentablocks were then synthesized by conjugation reaction between carboxylic, hydroxyl groups of D,L-Serine and hydroxyl-terminal groups of temperature sensitive triblock PCL-PEG-PCL. The synthesized products were analyzed by 1H-NMR and their molecular weights were measured by gel permeation chromatography (GPC). The sol-gel transition of pentablock was also investigated by the inverting test method. The pH dependent property of the pH sensitive moiety could be very useful for preparing drug carriers.


Keywords


pH/temperature sensitive, D,L-Serine, benzenesulfonyl chloride, pentablock.

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DOI: https://doi.org/10.15625/2525-2518/54/5A/12071 Display counter: Abstract : 93 views. PDF : 98 views.

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Published by Vietnam Academy of Science and Technology