SYNTHESIS OF TWO NEW HYDROXIMINOSTEROIDS FROM CHOLESTEROL AND THEIR BIOLOGICAL EVALUATION

Thu Thuy Thi Tran, Ha Thi Dinh, Baskar Salvaraja, Long Quoc Pham, Quang Dai Ngo, Nghi Huu Do, Jae Wook Lee

Abstract


A simple and efficient synthesis of two new hydroximinosteroidal derivatives (11, 13) from cholesterol was described. The cytotoxicity of these compounds, their intermediates were evaluated on human cancer cell lines including Hep-G2, HeLa and T98G. Compound 13 presented a potent antiproliferative effect to T98G cancer cell at 2.9 mM of IC50. In addition, the antimicrobial assay showed that two new oximes 11 and 13 were active against E. coli and S. aureus strain (MIC :50 mg/mL).

Keywords


cholesterol, hydroximinosteroid, HeLa, HepG2, T98G

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References


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DOI: https://doi.org/10.15625/2525-2518/57/5/13809 Display counter: Abstract : 334 views. PDF : 158 views.

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