Study on the ability of extracts from Cordyceps spp. biomass to prevent memory impairment in mice

Dang Hoang Quyen, Tran Thi Hoang Yen, Vo Thi Xuyen, Dinh Minh Hiep, Truong Binh Nguyen


Following screening acetylcholinesterase (AChE) inhibitory activity of 60 extracts from biomass of 10 Cordyceps spp. strains, 3 extracts with high AChE inhibitor activity, viz. polysaccharide DL0004 extract (51.80±1.41%), n-BuOH DL0006 extract (55.71±2.72%) and n-BuOH DL0015 extract (71.08±1.47%) were further tested for their ability to improve memory impairment in mice using two short-term memory impairment models: Y-maze model (Y-maze) and Novel Object Recognition model. Cordyceps was extracted at a dose of 100 mg/kg and 200 mg/kg three days before the intraperitoneal (i.p) injection of 2.4 mg/kg trimethyltin (TMT); and seven days later, the mice were tested on the models. Results on the Y-maze model showed that there was a statistically significant difference in combinatorial percentage among different combinations: DL0004.1 and TMT (p<0.01), TMT and DL0004.2 (p<0.05), TMT and DL0015.1 (p<0.01), TMT and DL0006.1 (p<0.05), TMT and DL0006.2 (p<0.05). For Novel Object Recognition model, the results also showed difference with statistical significance in the ratio of novel recognition  to familiar recognition among comparison combinations: TMT and DL0004.1 (p<0.001), TMT and DL0004.2 (p<0.05), TMT and DL0006.2 (p<0.05), TMT and DL0015.1 (p<0.001).


Cordyceps, acetylcholinesterase, galantamine, memory impairment, trimethyltin.

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